Sonic Hedgehog Induces Roof Plate

Sonic hedgehog shh is a secreted protein that is involved in the organization and patterning of several tissues in vertebrates.

Sonic hedgehog induces roof plate.

Tanabe et al 1995. B gene expression in cps from mcre. A a schematic diagram of rat e13 embryo microdissections of pre crossing explants from the dorsal. Sonic hedgehog shh is a secreted protein that is involved in the organization and patterning of several tissues in vertebrates.

Ericson et al 1995. Notice that atoh1 egfp progenitors arrows are present in otx2 upper roof plate but absent in lower roof plate. Embryos mutant for a deletion of syu d. After closure the neural tube forms a basal or floor plate and a roof or alar plate in response to the combined effects of shh and factors including bmp4 secreted by the roof plate.

Sonic hedgehog shh a cholesterol modified. It is the best studied ligand of the hedgehog signaling pathway others being desert hedgehog dhh and indian hedgehog ihh. Figure 1 sonic hedgehog induces semaphorin responsiveness in pre crossing commissural axons. Sonic hedgehog induces semaphorin responsiveness in pre crossing commissural axons.

Roof plate cells of the neural tube liem et al 1995 which specify a subset of interneurons in the dorsal neural tube lee. A a schematic diagram of rat e13. In vertebrates it is involved in organogenesis including the growth of digits on limbs and the organization of the brain. It plays a key role in the development of animals from insects to mammals.

The basal plate. Sonic hedgehog is a protein that in humans is encoded by the shh gene. Shh expression in the notochord and floor plate also sonic hedgehog induces floor plate gene expression 1427 figure s. Floor plate cells in vitro can also be induced in neural plate explants grown in contact with cells transfected shh roelink et al 1994.

After sonic hedgehog shh signalling from the notochord induces its formation the floor plate of the incipient neural tube also secretes shh. Once these axons reach the floor plate they switch off their responsiveness to chemoat. In addition motor neuron differentiation can be in duced in neural plate explants by a diffusible factor derived. Activation of mouse shh and hnf3 3 in wexp2 cshh transgenic embryos a j transverse sections through an 11 5 dpc transgenic embryo hybridized with hnf3 f a f and i mouse shh b d g and j and chick shh c e and h.

We show that the zebrafish sonic you syu gene a member of a group of five genes required for somite patterning is encoding shh. Embryos mutant for a deletion of syu display defects in patterning of the somites the lateral floor plate cells the pectoral fins.